Thank you for all your efforts on this study so far! 

Advarra System Updates

As you may know, Advarra is transitioning to the new CIRBI next-generation system, effective the week of 13-Jul-2026. While they work through this update, you should receive several emails from Advarra providing further instructions to activate your new account. Please be on the lookout for notices from the following Advarra email addresses:

• Notices@advarra.com

• No-reply@advarracloud.com 

Vanquish 3

We appreciate any questions for additional insight into participating in start up activities for the VK2735-303 study. We are internally evaluating and will be in touch with more information in late July 2026.  

Discontinuation of Study Treatment in IRT

• If a participant is off IP but continuing in the study, the sites should use the “Report Permanent Discontinuation of Study Treatment” action in IRT. That way we don’t continue to send IP for the patient.

• If a participant is skipping dosing, sites should record the visits with no drug assigned, so IRT captures the number of consecutive doses missed. The system will continue to send IP for the patient until they are discontinued.

• If a patient has been off IP for a long time, and site doesn’t know if they will resume, it probably would make sense to report permanent discontinuation of IP in IRT. If they are approved to restart drug in the future, we can reverse the permanent discontinuation of study drug status and provide next steps for the correct visit will restart at. 

Post Auto-Injector Survey

Please fill out this brief survey, linked here:  

Viking VANQUISH Studies - Post Auto-Injector Survey – Fill out form

To provide feedback and pain points on auto-injector transition. As a reminder, during conversations with participants regarding the use of auto-injectors, please be sure to highlight that self-injection is how VK2735 will be presented in the commercial setting. Getting comfortable with auto-injector use, having the ability to ask questions, and having access to training videos all while under very close medical care of the study team is a benefit of continuing participation

PEth Testing

PEth testing only occurs at unscheduled visits, meaning that there is not a specific designated kit. Please use a tube from extra supply kit when conducting this test.  

Subject eDiary  

It is important to remind subjects to complete their subject diary when dosing AND when they do not dose.  

If you have any questions or concerns, please reach out to your CRA.  

Site Communications reminder  

It is important to remember to include your site CRA on any relevant communications. This ensures your request is sent to the correct team and is actioned in a timely manner.