Announcements and Reminders

02-Jun-2026 Study Update

Site Investigational Product Subject Accountability Log | Part A | Update to include total volume administered.

18-May-2026 Study Update

Vanquish-3 Updates. Participant Hydration Reminder. MRL Queries. FAQ Study Discontinuation Guidance.

11-May-2026 Study Update

PI/Medical Monitoring Discussion - Malnutrition Reporting. Lab Processing Reminder. MRL Quick Reference Guide V8.0.

27-Apr-2026 Study Update

Review Concomitant Medications During Re-Consent. Autoinjectors. Update ePRO App. Malnutrition Assessment Updates. PI Drop-In Session Q&A Log. Updated eCRF Completion Guidelines. Site Hub Log In.

14-Apr-2026 Study Update

IP Expiry Memo Follow Up. Protocol Amendment V5.0 Materials. Vitamin Deficiency Reporting. MRL Malnourishment Assessments.

07-Apr-2026 Study Update

IP Expiry Memo Follow Up. PI Medical Monitoring Drop-In Q&A Log. Protocol Amendment V5.0 Materials. Vitamin Deficiency Reporting.

02-Apr-2026 Study Update

Protocol Clarification Letter #5. Study Protocol Clarification & Administrative Letters. IP Expiry Extension Memo. Updated Medpace Study Team List. MRL Assessment Testing Follow-up.

20-Mar-2026 Study Update

Medical Monitoring Drop-in Sessions. Updated Study Supply Request Form. MRL Malnourishment Assessment. EDC Updates. Site Hub Portal. Clarification on Data Entry Rollover.

11-Mar-2026 Study Update

Clarification on Data Entry Rollover. Please ensure you are not entering a transition date into EDC until the first monthly auto injector visit occurs.

10-Mar-2026 Study Update

Clarification on Malnutrition Collection and Supply Details. Adverse Events of Special Monitoring.

04-Mar-2026 Study Update

VK2735-301 IRT Updates. Site FAQ/Discussion Guide. Daylight Savings. Advarra ICF Changes.

27-Feb-2026 Study Update

PI/CRC Call Follow-Up. Autoinjector Injection Video. Pharmacy Manual. Advarra ICF Changes.

23-Feb-2026 Study Update

Auto Injector Roll Out & Supply Details. Drug Holiday and Restarting IP. MRL Reminders. Investigator's Brochure. Upcoming PI/CRC Teleconferences (PAV5.0 Training and Important Study Updates)

17-Feb-2026 Study Update

Initial Auto Injector & Supply Shipments BMI Dose Modifications Under PA5. MRL Reminders. Upcoming PI/CRC Teleconferences (PAV5.0 Training and Important Study Updates).

10-Feb-2026 Study Update

Upcoming PI/RC Teleconferences (PAV5.0 Training and Important Study Updates). IP Storage. BMI Down Titration. Visit Windows.

03-Feb-2026 Study Update

Upcoming PI/CRC Teleconferences. IP Storage Concerns Survey. Visit Guidance. Concomitant Medication. BMI Down Titration. IRT Quick Reference Guide V2.0. PCS Travel and Reimbursement Policy V3.

26-Jan-2026 Study Update

IP Autoinjector Storage Concerns Survey. IRT Reminder for Resuming IP After 2 Consecutive Missed Doses.

16-Jan-2026 Study Update

VANQUISH 301 Protocol Amendment 4.0 Materials. Laboratory Manual v4.0, dated 19-Dec-2025. Retention Reminders. Autoinjector Transition.

12-Jan-2026 Study Update

VANQUISH 301/302 Dose Dispensing Worksheet. Temperature Excursion Reporting Reminders. MRL Reminder. Autoinjector.

06-Jan-2026 Study Update

Study Reminders. Sharps Containers and Coolers Shipments. End of Study Stipend Clarification. PI/CRC Call Follow-up.

02-Jun-2026 Study Update

June 2, 2026

Thank you for all your efforts on this study so far! 

***Site* *Investigational Product Subject Accountability Log | Part A***

The Subject Accountability Log has been updated to include a column to document the total volume administered and was attached to a previous eBlast.

*This is corrected from the log provided Friday, 29May2026. The version and date have been added*

Sites are required to complete this accountability log documenting volume administered for all subjects still being dosed with a vial.

The only change was the addition of “total volume administered”