Announcements and Reminders

Battle for Retention Challenge Update 5

The VANQUISH-1 Viking Battle for Retention Challenge Mid-September Update. Including a Helpful Retention Tip.

17-Sep-2026 Study Update

Contraception Reminders for Female Participants. ClinTrak IRT Reminder for Assigning Replacement Autoinjectors. MRL Reminders. PI Drop-In Call Q&A

04-Sep-2026 Study Update

PI/Medical Monitoring Meeting Slide Deck. Dr. Bays Patient Retention Videos are Available to View on the Site Hub.

01-Sep-2026 Study Update

PI/Medical Monitoring Calls - 01-04 Sep 2026. Rapid Trials Feedback Survey (Please fill out a brief 5-minute survey)

Battle for Retention Challenge Update 4

The VANQUISH-1 Viking Battle for Retention Challenge End of August Update. Reminder to continue to submit retention tips for additional points!

28-Aug-2026 Study Update

PI / Medical Monitoring Calls - 01-04 September 2026 | Please join the Medpace and Viking Teams during one of the invites sent.

Battle for Retention Challenge Update 3

The VANQUISH-1 Viking Battle for Retention Challenge Mid-August Update. Including some helpful Retention Tips.

12-Aug-2026 Study Update

IRT Dispensation Guidance for Participants Who Return for Weekly Injection Between Monthly Visits. Data Entry Reminders. Pharmacy Manual V6.0 - Temperature Excursion Form & Malfunction Form

07-Aug-2026 Study Update

Medical Monitor Team Updates. Reimbursement for Food Subscriptions and Gym Memberships.

Battle for Retention Challenge Update 2

The VANQUISH-1 Viking Battle for Retention Challenge End of July Update. Including a Helpful Retention Tip.

24-Jul-2026 Study Update

Advarra System Updates. Vanquish 3. Discontinuation of Study Treatment in IRT. Post Auto-Injector Survey. PEth Testing. Subject eDiary. Site Communications Reminder.

Battle for Retention Challenge Update 1

The VANQUISH-1 Viking Battle for Retention Challenge First Update. Including Helpful Retention Tips.

02-Jul-2026 Study Update

PI/Medical Monitoring Drop-In Sessions. Advarra System Updates. Vanquish 3. Discontinuation of Study Treatment in IRT. Post Auto-Injector Survey.

18-Jun-2026 Study Update

Spanish Speaking Subject Reminders: Please be advised for Spanish speaking participants, the Vanquish studies have documents available in US and PR Spanish.

02-Jun-2026 Study Update

Site Investigational Product Subject Accountability Log | Part A | Update to include total volume administered.

18-May-2026 Study Update

Vanquish-3 Updates. Participant Hydration Reminder. MRL Queries. FAQ Study Discontinuation Guidance.

11-May-2026 Study Update

PI/Medical Monitoring Discussion - Malnutrition Reporting. Lab Processing Reminder. MRL Quick Reference Guide V8.0.

27-Apr-2026 Study Update

Review Concomitant Medications During Re-Consent. Autoinjectors. Update ePRO App. Malnutrition Assessment Updates. PI Drop-In Session Q&A Log. Updated eCRF Completion Guidelines. Site Hub Log In.

14-Apr-2026 Study Update

IP Expiry Memo Follow Up. Protocol Amendment V5.0 Materials. Vitamin Deficiency Reporting. MRL Malnourishment Assessments.

07-Apr-2026 Study Update

IP Expiry Memo Follow Up. PI Medical Monitoring Drop-In Q&A Log. Protocol Amendment V5.0 Materials. Vitamin Deficiency Reporting.

02-Apr-2026 Study Update

Protocol Clarification Letter #5. Study Protocol Clarification & Administrative Letters. IP Expiry Extension Memo. Updated Medpace Study Team List. MRL Assessment Testing Follow-up.

20-Mar-2026 Study Update

Medical Monitoring Drop-in Sessions. Updated Study Supply Request Form. MRL Malnourishment Assessment. EDC Updates. Site Hub Portal. Clarification on Data Entry Rollover.

11-Mar-2026 Study Update

Clarification on Data Entry Rollover. Please ensure you are not entering a transition date into EDC until the first monthly auto injector visit occurs.

10-Mar-2026 Study Update

Clarification on Malnutrition Collection and Supply Details. Adverse Events of Special Monitoring.

04-Mar-2026 Study Update

VK2735-301 IRT Updates. Site FAQ/Discussion Guide. Daylight Savings. Advarra ICF Changes.

27-Feb-2026 Study Update

PI/CRC Call Follow-Up. Autoinjector Injection Video. Pharmacy Manual. Advarra ICF Changes.

23-Feb-2026 Study Update

Auto Injector Roll Out & Supply Details. Drug Holiday and Restarting IP. MRL Reminders. Investigator's Brochure. Upcoming PI/CRC Teleconferences (PAV5.0 Training and Important Study Updates)

17-Feb-2026 Study Update

Initial Auto Injector & Supply Shipments BMI Dose Modifications Under PA5. MRL Reminders. Upcoming PI/CRC Teleconferences (PAV5.0 Training and Important Study Updates).

10-Feb-2026 Study Update

Upcoming PI/RC Teleconferences (PAV5.0 Training and Important Study Updates). IP Storage. BMI Down Titration. Visit Windows.

03-Feb-2026 Study Update

Upcoming PI/CRC Teleconferences. IP Storage Concerns Survey. Visit Guidance. Concomitant Medication. BMI Down Titration. IRT Quick Reference Guide V2.0. PCS Travel and Reimbursement Policy V3.

26-Jan-2026 Study Update

IP Autoinjector Storage Concerns Survey. IRT Reminder for Resuming IP After 2 Consecutive Missed Doses.

16-Jan-2026 Study Update

VANQUISH 301 Protocol Amendment 4.0 Materials. Laboratory Manual v4.0, dated 19-Dec-2025. Retention Reminders. Autoinjector Transition.

12-Jan-2026 Study Update

VANQUISH 301/302 Dose Dispensing Worksheet. Temperature Excursion Reporting Reminders. MRL Reminder. Autoinjector.

06-Jan-2026 Study Update

Study Reminders. Sharps Containers and Coolers Shipments. End of Study Stipend Clarification. PI/CRC Call Follow-up.

04-Sep-2026 Study Update

September 4, 2026

Thank you for all your efforts on this study so far! 

PI/Medical Monitoring Meetings Slide Deck

Please see the slide deck previously sent via email that was presented during the recent PI/ Medical Monitoring calls held on 01-04Sep2026. The Q&A log is forthcoming and will be distributed to support the updates and discussion around protocol changes.

We will have training during SIVs and additional group PI/CRC trainings in the coming months.

If you have any questions or concerns, please reach out to your CRA!

Patient Videos

Dr. Bays retention videos are now located on the Study Videos of this website.

Please see the links and password to share directly with the participants and site team to support the VANQUISH journey.

Measuring Success: https://vimeo.com/1219206826?share=copy

Treatment Support: https://vimeo.com/1219206825?share=copy

Passwords are both: VANQUISH

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