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Announcements and Reminders

Rowing for Retention Challenge Update 5

VANQUISH-2 Viking Rowing for Retention Challenge Mid-September Update. Reminder to continue to submit retention tips for additional points!

17-Sep-2026 Study Update

Contraception Reminders for Female Patients. Clarification of Hypoglycemia. ClinTrak IRT Reminder for Assigning Replacement. MRL Reminders. PI Drop-In Call Q&A

04-Sep-2026 Study Update

PI/Medical Monitoring Meetings Slide Deck. Dr. Bays Patient Retention Videos Now Available on Site Hub.

01-Sep-2026 Study Update

PI/Medical Monitoring Calls - 01-04Sep2026. Please fill out the brief Rapid Trials Feedback Survey

Rowing for Retention Challenge Update 4

VANQUISH-2 Viking Rowing for Retention Challenge End of August Update. Includes a helpful retention tip from a study site.

28-Aug-2026 Study Update

PI / Medical Monitoring Calls - 01-04 September 2026 | Rapid Trials Feedback Survey

Rowing For Retention Challenge Update 3

VANQUISH-2 Viking Rowing for Retention Challenge Mid-August Update. Reminder to continue to submit retention tips for additional points!

11-Aug-2026 Study Update

IRT Dispensation Guidance for Participants Who Return for Weekly Injection Between Monthly Visits. Data Entry Reminders. Pharmacy Manual V6.0 - Temperature Excursion Form & Malfunction Form

07-Aug-2026 Study Update

Medical Monitor Team Updates. Reimbursement for Food Subscription and Gym Membership.

Rowing For Retention Challenge Update 2

VANQUISH-2 Viking Rowing for Retention Challenge End of July Update. Reminder to continue to submit retention tips for additional points!

Rowing For Retention Challenge Update 1

VANQUISH-2 Viking Rowing for Retention Challenge First Update. Includes helpful retention tips for your reference.

24-Jul-2026 Study Update

Advarra System Updates. Vanquish 3. Discontinuation of Study Treatment in IRT. Post Auto-Injector Survey. PEth Testing. Subject eDiary. Site Communication Reminder.

02-Jul-2026 Study Update

PI/Medical Monitoring Drop-In Sessions. Advarra System Updates. Vanquish 3. Discontinuation of Study Treatment in IRT. Post Auto-Injector Survey.

18-Jun-2026 Study Update

Spanish Speaking Subject Reminders: Please be advised for Spanish speaking participants, the Vanquish studies have documents available in US and PR Spanish.

02-Jun-2026 Study Update

Site Investigational Product Subject Accountability Log | Part A | Update to include total volume administered.

11-May-2026 Study Update

PI/Medical Monitoring Discussion - Malnutrition Reporting. Study Procedure Reminder. Lab Processing Reminder. MRL Quick Reference Guide V8.0.

27-Apr-2026 Study Update

Review Concomitant Medication During Re-Consent. Autoinjectors. Update ePRO App. Malnutrition Assessment Updates. PI Drop-In Session Q&A Log. Updated eCRF Completion Guidelines. Site Hub Log In.

14-Apr-2026 Study Update

IP Expiry Memo Follow Up. Protocol Amendment V5.0 Materials. Vitamin Deficiency Reporting. MRL Malnourishment Assessments.

07-Apr-2026 Study Update

IP Expiry Memo Follow Up. PI Medical Monitoring Drop-In Q&A Log. Protocol Amendment V5.0 Materials. Vitamin Deficiency Reporting.

01-Apr-2026 Study Update

Protocol Clarification Letter #5. Study Protocol Clarification & Administrative Letters. IP Expiry Extension Memo. Updated Medpace Study Team List. MRL Assessment Testing Follow-Up

17-Mar-2026 Study Update

Medical Monitoring Drop-in Sessions. VK2735-302 IRT Updates. Updated Study Supply Request Form. MRL Malnourishment Assessment. EDC Updates. Site Hub Portal. Clarification on Data Entry Rollover.

11-Mar-2026 Study Update

Clarification on Malnutrition Collection and Supply Details. Clarification on Data Entry Rollover.

10-Mar-2026 Enrollment Status

The study has officially closed for screening and randomization. All subjects remaining in screening will be required to screen fail.

09-Mar-2026 Enrollment Status

Randomization remains open for VANQUISH-2. We recommend scheduling randomization visits promptly when eligibility is confirmed.

05-Mar-2026 Study Update

Enrollment Update: Randomization remains open for VANQUISH-2. Study Reminder for Daylight Savings: Ensure consideration is taken for the upcoming time change.

04-Mar-2026 Enrollment Status

Screening is now closed for VANQUISH-2. Additionally, approximately 50 randomization slots remain. Once these slots have been filled, randomization will be closed.

03-Mar-2026 Enrollment Status

At the time of this notification, there are approximately 0 screening slots available before screening will close. We expect this to happen at the end of day today or early tomorrow and will notify you once it has formally closed.

27-Feb-2026 Study Update

PI/CRC Call Follow-up. Autoinjector Injection Video. Study Reminders about the Pharmacy Manual and Advarra ICF Changes.

24-Feb-2026 Enrollment Status

We are excited to see the recent activity on screening and randomizations. There are approximately 75 screening slots remaining for VANUISH-2, which we expect to be filled in the next week.

23-Feb-2026 Study Updates

Auto Injector Roll Out & Supply Details. Drug Holiday and Restarting IP. MRL Reminders. Investigator's Brochure. Upcoming PI/CRC Teleconferences (PAV5.0 Training and Important Study Updates).

20-Feb-2026 Enrollment Status

There are approximately 100 screening slots remaining for VANQUISH-2. There has been an increase in screenings and randomizations last week and we want to ensure awareness that screening will close once these slots are filled.

17-Feb-2026 Study Update

Enrollment Updates. Initial Auto Injector & Supply Shipments. BMI Dose Modification Under PA5. MRL Reminders. Upcoming PI/CRC Teleconferences (PAV5.0 Training and Important Study Updates).

10-Feb-2026 Study Update

Upcoming PICRC Teleconferences (PAV5.0 raining and Important Study Updates). Enrollment Update. IP Storage. Visit Windows.

03-Feb-2026 Study Update

Upcoming PI/CRC Teleconferences (PAV5.0 Training). Enrollment Update. IP Storage Concerns Survey. Visit Guidance. Concomitant Medication. IP Dose Modification. PCS Travel and Reimbursement Policy V3.

26-Jan-2026 Study Updates

Enrollment Update. IP Storage Concerns Survey. IRT Reminder for Resuming IP After 2 Consecutive Missed Doses. ECG Acquisition and Submission Manual V5.0.

16-Jan-2026 Study Updates

VANQUISH 302 Protocol Amendment 4.0 Materials. Laboratory Manual v4.0, dated 19-Dec-2025. Study Update Recruitment: Nearing the Final Goal for Recruitment.

12-Jan-2026 Study Update

VANQUISH 301/302 Dose Dispensing Worksheet. Temperature Excursion Reporting Reminders. Update on Hypoglycemia Symptoms Diary and SMBG Data Reports. MRL Reminder. Autoinjector.

06-Jan-2026 Study Update

Enrollment Open. Sharps Container and Coolers Shipments. End of Study Stipend Clarification.

04-Sep-2026 Study Update

September 4, 2026

Thank you for all your efforts on this study so far! 

PI/Medical Monitoring Meetings Slide Deck

Please see the slide deck previously attached via email that was presented during the recent PI/ Medical Monitoring calls held on 01-04Sep2026. The Q&A log is forthcoming and will be distributed to support the updates and discussion around protocol changes.  

We will have training during SIVs and additional group PI/CRC trainings in the coming months.

If you have any questions or concerns, please reach out to your CRA!

Patient Videos

Dr. Bays retention videos are now located on the Study Videos Page

Please see the links and password to share directly with the participants and site team to support the VANQUISH journey.  

Measuring Success: https://vimeo.com/1219206826?share=copy  

Treatment Support: https://vimeo.com/1219206825?share=copy  

  • Passwords are both: VANQUISH

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